Gibb, AJ; Edmonds, B; Silver, RA; Cull-Candy, SG; Colquhoun, D; (2012) Activation of NMDA receptors. In: The NMDA Receptor. Full text not available from this repository. Abstract © Oxford University Press 1994. All rights reserved. Understanding the processes occurring during receptor activation is of fundamental importance to pharmacology, and activation of receptors such as the NMDA receptor, which have an integral membrane ion channel, has proved to be particularly amenable to study using single channel recording techniques. The activation of muscle and Torpedo acetylcholine receptors (AChRs) has been studied in great detail. Using these approaches the rates of the reactions involved in receptor activation have been estimated and for the endplate AChRs these rates are consistent with the observed rate of synaptic transmission at the neuromuscular junction. This has led to the expectation that new insights into the processes underlying the NMDA receptor-mediated component of excitatory post-synaptic currents (NMDA EPSCs) will be obtained from studies of NMDA receptor single channels. Type: Book chapter Title: Activation of NMDA receptors ISBN-13: 701 DOI: UCL classification: URI. The physiology of N-methyl-d-aspartate (NMDA) receptors is fundamental to brain development and function. NMDA receptors are ionotropic glutamate receptors that. Thus, NMDA receptors in different parts of the brain. Thus NMDA receptor activation leads to a calcium influx into the post-synaptic cells. NMDA receptors (NMDARs) are glutamate-gated cation channels with high calcium permeability that play important roles in many aspects of the biology of higher organisms. They are critical for the development of the central nervous system (CNS), generation of rhythms for breathing and locomotion, and. Thus, NMDA receptors in different parts of the brain. Thus NMDA receptor activation leads to a calcium influx into the post-synaptic cells. NMDA Receptor Function and Physiological Modulation. NMDA receptor activation leads to opening of an ion channel that is selective for cations, resulting in.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. Archives
April 2018
Categories |